To insure safe use of the food starchmodified, the label of the food additive container shall bear the name. Hydroxypropyl cellulose cellulose, 2hydroxypropyl ether is a derivative of cellulose with both water solubility and organic solubility. Hold time initial tempera final at final hydroxypropyl cellulose is. Hydroxypropyl cellulose an overview sciencedirect topics. Hpmc is hydrophilic water soluble, a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings.
Hydroxypropyl methylcellulose, 50 cps, fcc is most commonly used as an alternative to gelatin and gluten and is approved by fda as both a direct and an indirect food additive. Tell your doctor and pharmacist about all of your drugs prescription or otc, natural products, vitamins and health problems. A recent survey shows that lhpc is ranked as the first choice of tablet disintegrant by japanese pharmaceutical companies. Should you have any questions about the hydroxypropyl cellulose monograph, please contact dr. Hydroxypropyl cellulose is a kind of cellulose ether which is water soluble and contains a polymeric chain which allows the compound to be used in several enduse applications. However, hydroxypropyl cellulose a similar cellulose derivative has been tested in both rats and rabbits. Its semisynthetic in that it begins as cellulose, the carbohydrate building block of plant fiber. American polymer standards corporation safety data sheet page 2 of 5 hydroxypropyl methylcellulose section 5. The added hydroxypropyl group contains a hydroxyl group that also can be etherified during preparation of hydroxypropylcellulose.
Add 10 ml of chromium trioxide solution 30 g in 70 ml. Wash the contaminated area with soap and water sufficiently. The average number of substituted hydroxyl groups per glucose unit is referred to as the degree of substitution ds. In terms of physical appearance, hydroxypropyl cellulose is a white powder which is tasteless and odorless. Ac244020000, ac244020010, ac244020050, ac24402, ac244022500 synonyms. Hydroxypropyl cellulose sc252897 hazard alert code key. However, we make no warranty of merchantability or any other.
Remove person to fresh air and get medical attention skin contact. The information in this booklet presents the physical and chemical properties of klucel as developed in our research. The information in this msds is written in good faith, but no warranty is given, to what is. This product does not contain any chemicals known to state of california to cause cancer, birth defects, or any other reproductive harm. If you use hydroxypropyl cellulose on a regular basis, use a missed dose as soon as you think about it. The fcc grade meets the requirements of the food chemical cod. An idealized structure for a portion of a hydroxypropylcellulose molecule with a molar substitution ms of 3. Hydroxypropyl cellulose definition of hydroxypropyl. Hydroxypropylcellulose hpcsl and ssl, lowviscosity hydroxypropylcellulose polymers, are versatile pharmaceutical excipients. Firefighting measures suitable extinguishing media. Some typical molecular weight values are given in table i. Request pdf safety assessment of hydroxypropyl methylcellulose as a food ingredient hydroxypropyl methyl cellulose hpmc. Hydroxypropyl methylcellulose, also known as hypropmellose or e464, is a semisynthetic form of cellulose used to make gel caps. Material safety data sheet hydroxypropyl cellulose average.
Hydrochlorothiazide hctz 60 mg strength tablets containing commonly used excipients and hydroxypropyl cellulose, marketed as either klucelef hpc, nf from hercules, usa or hpcl hpc, nf from nippon soda, japan, as a binder were manufactured. Determination of viscoelastic and rheooptical material functions of. Pdf solgel behavior of hydroxypropyl methylcellulose hpmc in. Ac184880000, ac184880010, ac184880050, ac18488, ac184882500 synonyms. Lowviscosity hydroxypropylcellulose hpc grades sl and. Hydroxypropylmethyl cellulose 9004653 hydroxy3methoxybenzoic acid, 4 1246. It is inserted in the eye to relieve dryness and irritation caused by reduced tear flow that occurs in certain eye diseases. Effect of hydroxypropyl cellulose hpc on dissolution. Solgel behavior of hydroxypropyl methylcellulose hpmc in ionic. It is also used as a binder in ceramics and glazes, additive in hair and cosmetic products and blowmolded bottles. Food starchmodified as described in this section may be safely used in food.
Specifications of hydroxypropyl methylcellulose hpmc powders used. You must check to make sure that it is safe for you to take hydroxypropyl methylcellulose with all of your drugs and health problems. Sigmaaldrich offers a number of hydroxypropyl cellulose products. Klucel hydroxypropylcellulose hpc physical and chemical. When this occurs, the number of moles of hydroxypropyl groups per glucose ring, or moles of substitution ms, can be higher than 3. Chemical name cellulose, 2hydroxypropyl methyl ether chemical structure cas number 9004653 proportion range more than 95%. The fibrous reaction product is purified and ground to a fine, uniform powder. The relative heat capacity profiles depicting thermal behavior of hpmc sds. Gels from modified hydroxyethyl cellulose and ionic surfactants.
Safety assessment of hydroxypropyl methylcellulose as a. Uniis are generated based on scientific identity characteristics using iso 11238 data elements. Hpc is an ether of cellulose in which some of the hydroxyl groups in the repeating glucose units have been hydroxypropylated forming och 2 chohch 3 groups using propylene oxide. Hydroxypropyl cellulose 1600000 wamw synonyms and mappings. One study in rats indicated there was an increase in fetal resorptions, gross and skeletal malformations after a 1 and 4% hpmc i. Hydroxypropyl methylcellulose hpmc belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring fig. Procedure transfer about 65 mg of hydroxypropyl cellulose, previously dried at 105 for 1 hour and accurately weighed, into the reaction flask. This medicine is available only with your doctors prescription. Pdf solgel transformations in hpmc hydroxypropyl methylcellulose are being. However, its gelling temperature in hot water is significantly higher than that of methyl cellulose mc. Keep in mind that any accidents involving a chemical will require an sds to be provided to emergency personnel, and to the attending physician so proper.
Safety assessment of hydroxypropyl methylcellulose. Hydroxypropyl cellulose belongs to the group of medicines known as artificial tears. Difference between methyl cellulose mc and hydroxypropyl methyl cellulose hpmc 1. Common name hydroxypropyl methylcellulose chemical name cellulose, 2 hydroxypropyl methyl ether chemical structure cas number 9004653 proportion range more than 95% 4.
Scaling concepts in polymer physics, cornell university press, ithaka 1979. Further, it is used in contact lens wetting solutions, as a formulation aid and texturizer for foods. American polymer standards corporation safety data sheet. The quantity of any substance employed to effect such modification shall not exceed the amount reasonably required to accomplish the intended physical or technical effect, nor exceed any limitation prescribed.
In cosmetic and personal care product formulations it is used as a binder, emulsion stabilizer, film former, and a vis. Aspirin or calcium will return items that have strings like aspirin glycine and glycine calcium because they contain at least one of the terms in the search. Assemble the apparatus as shown in figures 1 and 2, and immerse the reaction flask in the oil bath slightly above the level of the chromium. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Florasomes jojoba provides fragrance and color signals to enhance the formulas appeal. Do not start, stop, or change the dose of any drug without checking with your doctor. The hydroxypropyl cellulose monograph will be incorporated into and become official with the second supplement to usp 37nf 32. Cellulose alone or in combination with other matrixes has been employed in food packaging applications. Along with its needed effects, a medicine may cause some unwanted effects. The macroscopic properties of aqueous solutions of hydroxyethyl cellulose hec and of modified. Combined compendium of food additive specifications online help about the data general specifications for enzymes analytical methods volume 4. Material safety data sheet hydroxypropyl cellulose average mol. Use dry chemical powder, water spray fog, foam or co2 unsuitable extinguishing media. Cellulose derivatives such as methylcellulose, hydroxypropyl cellulose, and carboxymethyl cellulose cmc are being extensively used to produce films due to their suitable properties sanlaead et al.
Hydroxypropyl methylcellulose is produced by treating heated cellulose fibers with a caustic solution which in turn is reacted with methyl chloride and propylene oxide yielding the propylmethyl ether of cellulose. Find patient medical information for hydroxypropyl cellulose on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Extreme high moderate low section 1 chemical product and company identification product name hydroxypropyl cellulose statement of hazardous nature not considered a hazardous substance according to osha 29 cfr 1910. Do not use 2 doses at the same time or extra doses. Hemcmc hydroxyethylmethycarboxymethyl cellulose hpc.
Our msds database is an easy to use, do it yourself tool, and best of all. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Floraesters k100 jojoba provides a substantive, pleasant, and smooth skin feel to this mask. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy.
Search results for hydroxypropyl methylcellulose at sigmaaldrich. Hydroxypropyl methylcellulose, and cellulose gum hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxy propyl methylcellulose, and cellulose gum are modified cellulose polymers that are used. Although not all of these side effects may occur, if they do occur they may need medical attention. Lacrisert hydroxypropyl cellulose ophthalmic dosing. One reagent lane fair lawn, nj 07410 for information in north america, call. Hydroxypropyl cellulose is used as an emulsifier, stabilizer, whipping aid and thickener.
Hydroxypropyl methyl cellulose is easily soluble in cold water but difficult to be soluble in hot water. The utility of hpc polymers was assessed for both dissolution enhancement and sustained release of pharmaceutical drugs using various processing techniques. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Hypromellose, short for hydroxypropyl methylcellulose hpmc, is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlleddelivery component in oral medicaments, found in a variety of commercial products as a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. Used as a emulsifier, stabilizer, whipping aid, protective colloid, film former or thickener in foods.
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